In Pseudomonas fluorescens Pf0-1 the availability of inorganic phosphate (Pi) is an environmental signal that controls biofilm formation through a cyclic dimeric GMP (c-di-GMP) signaling pathway. In low Pi conditions. a c-di-GMP phosphodiesterase (PDE) RapA is expressed. depleting cellular c-di-GMP and causing the loss of a critical outer-membrane adhesin LapA from the cell surface. https://herbsdailyes.shop/product-category/eye-preparations/